Previous research has suggested that the MCD diet can reduce the cortical area of NeuN+ signal, likely due to neuroinflammation or neuronal damage associated with liver dysfunction and metabolic stress [60], However, ketamine’s known ability to activate adult-born immature granule neurons could counteract these effects, leading to an increase in NeuN+ labeling [71]. This evidence concerns the gene RBFOX3 and Decreased liver function.