Among these, 50 genes are predominantly associated with all types of AD, including APP, PSEN1, PSEN2, APOE, MAPT, IDE, IGF2, GSK3B, HFE, ABCA7, IL1B, BACE1, APOC1, SOD2, CST3, IGF1R, ATP5F1A, BIN1, ABCA7, ACE, PLAU, and TREM2 [150]. This evidence concerns the gene APP and Alzheimer disease.