Among these, 50 genes are predominantly associated with all types of AD, including APP, PSEN1, PSEN2, APOE, MAPT, IDE, IGF2, GSK3B, HFE, ABCA7, IL1B, BACE1, APOC1, SOD2, CST3, IGF1R, ATP5F1A, BIN1, ABCA7, ACE, PLAU, and TREM2 [150]. Here, PSEN1 is linked to Alzheimer disease.