Three males with PTPN11 variants developed other malignancies: one subject had testicular juvenile granulosa cell tumor that required surgical excision, one was diagnosed with dysembryoplastic neuroepithelial tumor (DNET) at the age of six during radiological examinations conducted to investigate focal epilepsy (no therapy was performed), and one had a glioma diagnosed at 22 months of life that required specific treatments. Here, PTPN11 is linked to central nervous system cancer.