TP53 and prion disease: Different from the mESC data, KEGG analysis of the up-regulated DEGs in bESCs in the MT versus CT condition showed that they were enriched with cell death and stress-related events (padj < 0.05), including ferroptosis, cell senescence, p53 and FOXO signaling pathways, reactive oxygen species (ROS), and oxidative phosphorylation, as well as a number of neural degenerative diseases, including Alzheimer’s, Huntingdon’s, Parkinson’s, and prion diseases and amyotrophic lateral sclerosis (Figure 5D, left).