THBS2 and epilepsy: In another study, Bronisz et al. [15] assessed the serum levels of molecules associated with changes in BBB structure in patients with epilepsy: matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9), tissue inhibitors of MMP-1 and MMP-2 (TIMP-1 and TIMP-2), the S100 calcium-binding protein beta (S100B), the chemokine CCL-2, intercellular adhesion molecule-1 (ICAM-1), P-selectin, and thrombospondin-2 (TSP-2).