Histone lactylation (e.g., VEGFA) helps to establish immunity homeostasis and activate the cardiac repair process in a timely manner.A feedback loop between H3K9la and HDAC2 drives VEGF-induced angiogenesis. Exercise-induced MECP2K271la may attenuate atherosclerosis in patients with metabolic disorders by suppressing vascular adhesion molecules (e.g., ICAM-1) and promoting anti-inflammatory pathways. This evidence concerns the gene VEGFA and metabolic disease.