In regard to experiments using replication-competent virions, a significant reduction in U2AF1 expression was observed in cells infected with the HIV-2 1806 isolate (* p < 0.05), while CASP3 expression showed a significant downregulation after infection with the HIV-2 1654 isolate (* p < 0.05); however, the expression of SKOR2 remained unaffected across all HIV-2 primary isolates. This evidence concerns the gene CASP3 and infection.