Focusing on breast cancer, it has also been shown that, in addition to spontaneous progression, accelerated progression can be present as a result of chemotherapeutic treatment, which triggers the progression of apoptosis to secondary necrotic or pyroptotic-like cell death in the tumor microenvironment through the caspase-3-mediated cleavage of GSDME [11,63]. The gene discussed is CASP3; the disease is neoplasm.