Families with mutations in the CDKN2A gene often show a high occurrence of clinically atypical, yet benign, nevi, as well as a familial tendency towards melanoma [21].The CDKN2A gene comprises four exons (1α, 1β, 2, and 3), encoding two proteins: p16 (encoded by exons 1α, 2, and 3) and p14ARF (encoded by exons 1β, 2, and 3). Here, CDKN2A is linked to melanoma.