NB cells (CHP-212, SH-SY5Y) expressed neurokinin-1 and -2 receptors and preprotachykinin I. Both receptors mediated the proliferation of NB cells; truncated and full-length neurokinin-1 receptors were observed in these cells; and neurokinin-1 receptor suppression decreased the proliferation of NB cells [67]. The gene discussed is TACR1; the disease is neuroblastoma.