sPEP1, a small 51-amino acid peptide, favored the self-renewal and aggressiveness of NB stem cells and exerted oncogenic actions by promoting the interaction of the SMAD family member 4 (SMAD4) and the eukaryotic translation elongation factor 1 alpha 1 (eEF1A1) [62]. The gene discussed is EEF1A1; the disease is neuroblastoma.