Studies have indeed proved that the tankyrases are particularly important in intestinal malignancy; the tankyrases’ inhibitors suppressed both, the Wnt signaling and the tumor growth in APC-mutant colorectal tumors [131,132,133,134,135,136,137,138], also decreasing the multi-drug resistance in TANKS-over-expressing colorectal cancer [138]. This evidence concerns the gene TNKS and colorectal cancer.