TCHP and breast cancer: Similarly, the compound xanthohumol, a chalcone isolated from Humulus lupulus, incubated with breast cancer cell line MCF-7/ADR [170] indicated the ability to suppress the estrogen signaling pathways (via tumor suppressor protein prohibitin2 modulation) and the expression of the anti-apoptosis proteins, at the same time to induce cell cycle perturbation and to sensitize the cancer cells to radiation treatment.