MAPK8 and gastric cancer: Studies on the human gastric cancer cell line (BGC823) indicated the ability of phloretin to inhibit both, cell growth and cell invasion in vitro; specifically, it was proved the ability of phloretin to produce the cell cycle arrest in the G2/M phase at the same time to inhibit the c-Jun N-terminal kinase (JNK) signaling pathway in cells [166].