Most patients had lymph node metastases (LNM; PD‐1: 32.4%; BRAF + MEK: 37.5%), sole distant metastasis (M) or the combination of LNM and M was found in 9 (26.8%) patients in the PD‐1 and 12 (37.5%) in the BRAF + MEK cohort, whereby distant metastases predominantly involved the skin (PD‐1: 8.8%; BRAF + MEK: 9.4%). Here, MAP2K7 is linked to metastatic malignant neoplasm in the lymph nodes.