Administration:• Tablet: Take with food• Suspension: Shake well before use; take with foodMost common side effects: Diarrhea, nausea, headacheDrug interactions: Screen for drug interactions†Contraindications: Inhibits CYP3A enzyme resulting in many contraindications with medications, drug interaction review is criticalCautions: DRV must be co-administered with RTV or COBI; risk for Stevens-Johnson syndrome and toxic epidermal necrosis; can cause hepatotoxicity; use with caution in persons with known allergy to sulfonamide medications. The gene discussed is CYP3A4; the disease is Stevens-Johnson syndrome.