We found that CUMS reduced the number of FABP7‐GFAP cells in the CA1 (t(4) = 18.79, p < 0.001; Figure 4A,C), CA3 (t(4) = 4.152, p < 0.05; Figure 4A,D), and DG (t(4) = 2.850, p < 0.05; Figure 4A,E) subregions of the HP, and FABP7 overexpression reversed the phenomenon in the CA1 (t(4) = 4.745, p < 0.01; Figure 4B,F), CA3 (t(4) = 14.67, p < 0.001; Figure 4B,G), and DG (t(4) = 3.650, p < 0.05; Figure 4B,H) subregions of the HP, which further validated the astrocyte specificity of FABP7 in the mechanism of depression. This evidence concerns the gene GFAP and depressive disorder.