Encoded by the CD-63 gene, this protein is associated with intracellular vesicles inducing functions on the cell surface like cellular signalling for growth, proliferation and motility.122,123 Platelet activation is one of its recognised roles,124 as well as involvement in abnormal cellular growth leading to tumour formation.125,126 The exact role of CD-63 in tumorigenesis is a bit controversial with some studies reporting a negative relationship and a few reporting a positive relationship. The gene discussed is CD63; the disease is neoplasm.