Belonging to the four-member syndecan proteoglycan family, this protein is an integral membrane protein with a central core protein with multiple glycosaminoglycans (both chondroitin sulfate and heparin sulfate) side chains.104 Due to the involvement of syndecan-1 in cellular processes like proliferation, migration and other cell-cell matrix interactions, it positions itself as an important protein during tumour growth and invasion.105 The expression of Syndecan-1 in each tumour type is contextual and its relevance depends on the cell type and its significance. This evidence concerns the gene PROS1 and neoplasm.