In contrast, although the COVID-19 group showed increased proportional usage of several different TRAV-TRAJ combinations, with enrichment of TRAV3-2 in the CD4 population, and TRAV21 in the CD8 population, we found no differences in proportional non-productive TRAV × TRAJ combinations between the COVID-19 and healthy control groups. This evidence concerns the gene CD8A and COVID-19.