NPY and Fabry disease: Three RCTs (Dong et al., 2023; Zhou et al., 2020; Lu and Zhang, 2019) showed that compared to conventional therapy, therapeutic massage combined with conventional therapy significantly increased the level of NPY in children with FD (MD = 1.62; 95% CI 0.37 to 2.87, I2 = 95%, P = 0.01; Figure 8) but the heterogeneity is high.