Three RCTs (Yu et al., 2024; Cui and Zhao, 2024; Zhou et al., 2019) showed that compared to conventional therapy, therapeutic massage combined with conventional therapy significantly increased the level of gastrin in children with FD (MD = 21.83; 95% CI 9.43 to 34.23, I2 = 93%, P < 0.001; Figure 8) but the heterogeneity is high. This evidence concerns the gene GAST and Fabry disease.