ADAR and cancer: In the context of cancer, endogenous-ADAR present an additional noteworthy advantage; Expression levels of the natural ADAR enzymes (both ADAR1 and ADAR2) are rather high in most cancer types and the expression levels of the main editing enzyme, ADAR1, is known to be elevated in most cancer types [24], which may contribute to the efficacy of the treatment, as well as an increased selectivity to cancer versus non cancer cells.