Several studies used ARPE‐19 cells to represent RPE cells for models of eye diseases because the differentiation of ARPE‐19 cells can express RPE‐specific markers, including RPE65 and CRALBP, that achieve phenotypic characteristics closer to those of native RPE cells, especially when studying retinal pathophysiology and treatment effects (Dunn et al. 1996; Samuel et al. 2017). The gene discussed is RPE65; the disease is eye disorder.