AQP4 and Cognitive impairment: While it is known that AQP4 deletion amplifies cognitive deficits in 12‐month‐old APPPS1 mice by increasing Aβ accumulation,69 it has not been clear until now whether pharmacological inhibition can have the same effect in a short amount of time and whether AQP4 facilitation can rescue the APPPS1 phenotype and restore the behavioral pattern of the WT group.