In contrast, no statistically significant difference in the composite risk of sepsis was found between the two transfusion strategies for the LTS group with a threshold of Hb ≤ 10 mg/dl (RR 1.42; 95% CI 0.87–2.32; p = 0.16; I2 = 0%; Fig. S23 in Supplementary information S1). Here, GSTM1 is linked to Sepsis.