The top most frequent 10 AEs were pyrexia (461 cases), vomiting (434 cases), aspartate aminotransferase increase (284 cases), alanine aminotransferase increase (260 cases), hepatic enzyme increase (237 cases), thrombocytopenia (170 cases), platelet count decrease (140 cases), liver function test increase (116 cases), troponin I increase (113 cases) and pneumonia (112 cases), (Table 4). This evidence concerns the gene GPT and Thrombocytopenia.