In the group with AD, the model fit was significant (F [5, 9] = 4.105, p = 0.032, R2 = 0.695) and mGluR5 was the only significant predictor (β = 0.236, η2 = 0.572, p = 0.007) of synaptic density, consistent with our initial analysis. The gene discussed is GRM5; the disease is Alzheimer disease.