CALR and colorectal carcinoma: Treating CRC cells with OSW-1 markedly induced mRNA expression of TNFA and IFNB1, along with cell-surface level of the ER chaperone calreticulin (CRT), a pro-phagocytic signal to promote DC maturation, antigen presentation, and cytotoxic T cell priming [36], in a PUMA-dependent manner (Supplementary Fig. 7A, B).