RB1 and neuroendocrine neoplasm: Recurrent deleterious MEN1, DAXX, RB1, and TP53 mutations were observed in pancreatic (PanNENs) and pulmonary (PulNENs) neuroendocrine neoplasms while activating RET mutations were found in medullary thyroid carcinomas (MTCs) (Fig. 1a; Supplementary Table 3).