TRAIL can bind to two death receptors (TRAILR1 or DR4 and TRAILR2 or DR5) triggering apoptosis, but also to three decoy receptors (DcR1, DcR2, OPG) which can interfere with TRAIL-mediated apoptotic signals and contribute to TRAIL resistance of normal cells and cancer cells10. This evidence concerns the gene TNFRSF10A and cancer.