GAK and Parkinson disease: Genome-wide association analysis of patients with familial PD revealed an association between single nucleotide polymorphisms at the GAK locus and PD susceptibility,365 which was supported by followed-up meta-analyses.366–369 Cyclin G-associated kinase (GAK) encoded by the GAK gene is a Ser/Thr kinase comprised of a kinase domain in the N-terminus and a clathrin binding domain.370 Neuron-specific knockout of GAK leads to cell loss in neonatal mice due to deficient proliferation of neural progenitors,371 and GAK inhibition is associated with neurodevelopmental disorders.372