As a ubiquitously expressed Ser/Thr kinase, GSK3β activity in the peripheral blood of AD patients is positively correlated with the degree of dementia.205 GSK3β mainly affects the pathology of AD, including Aβ formation, tau pathology, neuronal survival and apoptosis, oxidative stress, and neuroinflammation. The gene discussed is MAPT; the disease is Alzheimer disease.