Further exploration of the TCGA database identified ZIP8 protein overexpression across multiple cancer types, including bladder cancer (BLCA), cervical cancer (CESC), esophageal cancer (ESCA), glioblastoma (GBM), kidney cancers (KIRC, KIRP), pancreatic cancer (PAAD), prostate cancer (PRAD), Pheochromocytoma and Paraganglioma (PCPG), Sarcoma (SARC), Skin Cutaneous Melanoma (SKCM), Stomach adenocarcinoma (STAD) and Uterine Corpus Endometrial Carcinoma (UCEC) (Fig. 2C). This evidence concerns the gene SLC39A8 and esophageal cancer.