SLC39A8 and esophageal squamous cell carcinoma: In order to verify the effect of Nobiletin on ZIP8 in ESCC cells, we knocked down ZIP8 in KYSE30, KYSE450, and KYSE510 cell lines and treated them with different concentrations of Nobiletin (0 μM, 10 μM, 20 μM, and 40 μM).