AKT1 and major depressive disorder: It consists of an inositol head and a diacylglycerol tail, which are also the source of the important second messengers IP3 and DAG downstream of the future formation of the phosphatidylinositol pathway, and is an important molecule in the PI3K/AKT signaling pathway involved in a variety of disease processes, including cancer [32], depression [33], diabetes [34], CKD and so on [35,36].