SQSTM1 and cancer: Tiliroside is a potential natural anti-cancer product that can target TBK1 to reduce the phosphorylation level of serine 349 on sequestosome-1 (p62), thereby decreasing the affinity of p62 for Kelch-like ECH-associated protein 1 (Keap1) and promoting Keap1-mediated ubiquitination and degradation of NRF2, which induces ferroptosis in hepatocellular carcinoma [162].