WDR76 and lung carcinoma: Lymphospecific helicase (LSH) in lung cancer activates metabolic genes by modifying DNA methylation through WD repeat domain 76 (WDR76) to reduce lipid ROS levels and inhibit ferroptosis [113], where LSH action is antagonized by DDB1- and CUL4-associated factor 8 (DCAF8) [114].