Unlike the more pronounced reactivation events observed in immunosuppressed individuals, which show the typical pattern of de novo HBV reactivation, usually marked by significant ALT elevations, clinical hepatitis flares, and, in some cases, hepatic decompensation, the cases reported so far appear more consistent with relapses after incomplete viral clearance in individuals who have not achieved a full functional cure. The gene discussed is GPT; the disease is Hepatitis.