In addition to elevated antibody titres against the EBNA complex and EBNA1 antigen,106 people with MS have more EBNA1 reactive CD4+ T cells,108 which respond to a more extensive repertoire of epitopes distributed across the EBNA1 protein.108 In comparison, T cells from healthy controls only react to the immunodominant portion of the protein.109. This evidence concerns the gene CD4 and myeloid sarcoma.