Our group and others have previously found that systemic chemokines are associated with AMD, including C-C motif chemokine ligand 2 (CCL2), CCL3, CCL4,12–14 as well as chemokine receptors C-C motif chemokine receptor type 1 (CCR1),15 CCR2,15,16 CCR5,17–19 CCR6,18 C-X-C motif chemokine receptor type 3 (CXCR3),18–21 and C-X3-C motif chemokine receptor type 1 (CX3CR1).16 The gene discussed is CX3CR1; the disease is age-related macular degeneration.