For example, Ndfip1 (Figure 5—figure supplement 2B) encodes a regulatory protein that enhances the activity of the ubiquitin ligase ITCH to negatively regulate inflammation (Oliver et al., 2006; Altin et al., 2014) and has been associated with asthma risk in GWAS studies (Ferreira et al., 2011). Here, ITCH is linked to asthma.