Among the modest number of genes identified via association mapping at chromosome 18 are Rnf125 and Klhl14, tumor suppressors that are each involved in several cancers (Kodama et al. 2022; Draškovič et al. 2024), including Klhl14 in B-cell lymphoma (Choi et al. 2020). The gene discussed is KLHL14; the disease is cancer.