We have recently generated an MYC-driven liver cancer genetic model (ABC-Myc mouse) and derived cell lines such as NEJF10 (Fang et al., 2023), which are readily cultured in 2D and 3D conditions (Figure 1—figure supplement 1A), and which are suitable for genome-wide genetic screenings (Fang et al., 2023). The gene discussed is MYC; the disease is liver cancer.