MELTF and melanoma: Once confirmed, dose-dependent phototoxicity of L49(scFv)-SNAP-IR700 was achieved on illuminated MTf-positive cell lines showing IC<sub>50</sub> values in the nanomolar range (2.20-5.24 nM).<h4>Conclusion</h4>This study highlights the therapeutic potential of MTf as a promising target for the diagnosis as well as selective and efficient elimination of NIR-light-accessible melanoma and TNBC by NIR-PIT.<h4>Trial registration</h4>NCT03769506.