Endogenous astrocytic tau is required for astrocyte‐mediated synaptotoxicity induced by Aβ and the accumulation of brain‐derived AD tau fibrils induces a more robust inflammatory and neurotoxic phenotype in human astrocytes, highlighting the nature of tau fibrils as an important contributing factor to inflammation and neurodegeneration in AD [24]. This evidence concerns the gene MAPT and Alzheimer disease.