These investigations encompass the evaluation of hormones and symptoms (hormonal syndromes), determination of tumor differentiation and proliferation (tumor grade), and utilizing positron emission tomography/computed tomography (PET/CT) with gallium(Ga)‐68 labeled somatostatin analogs (SSA), such as 68Ga‐DOTATOC and [18F]fluorodeoxyglucose (FDG) to assess tumor stage, as well as somatostatin receptor (SSTR) status and metabolic activity. The gene discussed is SST; the disease is neoplasm.