ESRRA and Sepsis: By using Cecal Ligation and Puncture (CLP) method, sepsis mouse model was constructed based on the transgenic mouse established in Fig. 1A and combined with neurological score (≤ 6 points) to establish a sepsis-associated brain dysfunction (SABD) mouse model, namely Errα-KO-SABD and WT-SABD (control group) (Fig. 1B).