Impairment of the PI3K/AKT pathway during Alzheimer’s disease progression, coupled with successive mTOR stimulation, has been shown to enhance tau phosphorylation, amyloid-beta deposition, and the cessation of autophagy, thereby exacerbating neurodegeneration (Cai et al. 2015). Here, PIK3CG is linked to early-onset autosomal dominant Alzheimer disease.