SCN9A and neuroma: In humans, the voltage gated sodium channel (VGSC) Nav1.7 is known to be expressed in sensory neurons, including all human nociceptors41,46, and in painful neuromas (41–43) which are suspected to give rise to ectopic activity as has been evidenced by the efficacy of VGSC blockers in experimental (44–47) and human neuromas (48).