HSPG2 and hepatocellular carcinoma: Although it is recognized that hepatic progenitor cells contribute to the development of PLC, some fate-tracing animal studies suggest that HCC rarely originates from resident hepatobiliary hybrids or hepatic progenitor cells at least in some HCC models in mice (Font-Burgada et al. 2015; Mu et al. 2015; Sia et al. 2017).