TP53 and intrahepatic cholangiocarcinoma: For example, p53, a key transcription factor in senescence, has a repressive role in Nestin expression in liver progenitor cells, and loss of p53 (thus, Nestin upregulation) together with either WNT or NOTCH signaling promotes HCC or ICC development, respectively (Tschaharganeh et al. 2014).