MYC levels have also been shown to affect the lineage commitment in PLC, where high levels of Myc drive HCC formation by activating Forkhead family transcription factors FOXA1 and FOXA2, while low MYC levels allow ETS1 to promote ICC development (D'Artista et al. 2023). The gene discussed is FOXA2; the disease is hepatocellular carcinoma.