Given the association of redox imbalance with several neuropsychiatric disorders and the key role of the NRF2 pathway in counteracting oxidative stress, numerous studies continue to reveal the significant involvement of NRF2 in conditions such as major depressive disorder, bipolar disorder, schizophrenia, and attention deficit hyperactivity disorder (ADHD) [23,24]. Here, NFE2L2 is linked to major depressive disorder.