PCNA and gastric cancer: The process of Oridonin treating gastric cancer involves Apaf-1 (apoptotic protease activating factor-1),[125] Caspase-3[125] cytochrome c,[125] CdK1 (cyclin-dependent kinases 1),[126] and cyclin β,[126] c-Met,[127] mitochondrial signal,[128] caspase-3,[129] VEGF (vascular endothelial growth factor),[130] integrin β,[130] PCNA (proliferating cell nuclear antigen)[130] and other pathways and elements.