It is worth noting that Oridonin can enhance MAPK activation by upregulating BMP7 (bone morphogenetic protein 7)[122] and reduce PTEN (phosphatase and tensin homologue) phosphorylation[123] to achieve therapeutic goals, as AMPK/mTOR/ULK1 can induce apoptosis in colorectal cancer cells.[124] Interestingly, Oridonin upregulation of BMP7, p38, and P35 elements will enhance Oridonin induction effect,[75] achieving a positive cycle. Here, PTEN is linked to colorectal cancer.