Furthermore, dysregulated signaling pathways, including the PI3K/AKT/mTOR and the EGFR, are frequently observed in HNSCC.[11,12] These pathways play crucial roles in cell growth, survival, and migration, and their dysregulation can promote tumor development and therapy resistance.[13,14] Therefore, understanding the molecular mechanisms underlying HNSC can pave the way for the development of targeted therapies. Here, EGFR is linked to neoplasm.