AIFM1 is a protein located on chromosome Xq26.1 and plays a vital role in apoptosis.[28] Several studies have shown that AIFM1 can induce apoptosis to impede tumor development.[29–31] However, our results revealed that AIFM1 acts as an oncogene and is highly expressed in HNSC. Here, AIFM1 is linked to neoplasm.