Moreover, IL1RAP is overexpressed in various tumors, including pancreatic cancer and triple-negative breast cancer,[36,37] and elevated IL1RAP promotes tumor development through multiple oncogenic signaling pathways.[38,39] Similarly, we discovered that IL1RAP is upregulated in HNSC and strongly correlated with poor prognosis. This evidence concerns the gene IL1RAP and familial pancreatic carcinoma.