IQGAP3 and ovarian carcinoma: Studies have found that the expression of IQGAP3 is increased in high-grade serous ovarian cancer, and the proliferation, migration and invasion of ovarian cancer cell are inhibited when IQGAP3 is silenced.[30] Interestingly, high expression of IQGAP3 appears to be associated with tumor mutational burden, microsatellite instability, immune cell infiltration, and immunomodulatory agents, with integral roles in the progression and immune response of various human cancers.[31] IQGAP3 expression was negatively correlated with dendritic cells resting, but positively correlated with B cells naive.