CCNE1 and neoplasm: In CCNE1-overexpressing tumor cells, aberrant p53 further lost control of the G1-S checkpoint, increasing the dependence on S phase and, more importantly, survival dependence on the G2-M cell cycle checkpoint.[23–25] CCNE1 is an oncogene in many tumors, and its elevated expression was further found to be associated with poor outcomes and platinum resistance.[26–28] In this study, CCNE1 expression was negatively correlated with T cells CD4 memory resting and Neutrophils, but positively correlated with B cells memory and macrophages M0 in UCEC.