By analyzing highly cocited references and highly cited references, we found that the research focus of osteoimmunology and OP is mainly about the molecular mechanism of OC activation and differentiation, including RANKL/RANK/OPG, WNT, Th17, NFATc1, ROS, etc. Through the keyword burst, we found that “postmenopausal osteoporosis,” “estrogen receptor alpha,” and “immune” are the current research hotspots and trends. This evidence concerns the gene ESR1 and postmenopausal osteoporosis.