SERPINE1 and triple-A syndrome: Given that plasminogen activator inhibitor 1 (PAI-1) plays an important role in human pathobiology and epigallocatechin-3-gallate (EGCG) exerts vasculoprotective actions, we investigated the role(s) of PAI-1 and the protective effect of EGCG in the mechanism of AAA formation, with a focus on inflammation, oxidative stress, proteolysis, and apoptosis in vivo and in vitro.