KRT19 and intrahepatic cholangiocarcinoma: A 2019 meta-analysis assessed the robustness of cytokeratin-19 fragment (CYFRA21-1) for diagnosing ICC and reported an AUROC of 0.904 (SE 0.0171), SEN of 0.81 (95% CI 0.75-0.86), and SPC of 0.86 (95% CI 0.82-0.89) [21].